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Mitochondrial DNA variation in human metabolic rate and energy expenditure |
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| Authors: | Tranah Gregory J Manini Todd M Lohman Kurt K Nalls Michael A Kritchevsky Stephen Newman Anne B Harris Tamara B Miljkovic Iva Biffi Alessandro Cummings Steven R Liu Yongmei |
| Institution: | aCalifornia Pacific Medical Center Research Institute, San Francisco, CA, 94107, USA;bUniversity of Florida, Department of Aging and Geriatric Research, Gainesville, FL, 32601, USA;cDepartment of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA;dLaboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, , MD, 20892, USA;eSticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA;fDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA;gLaboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, 20892, USA;hCenter for Human Genetic Research, Massachusetts General Hospital, Boston, MA, 02114, USA;iDepartment of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA;jProgram in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA, 02142, USA |
| Abstract: | The role of climate in driving selection of mtDNA as Homo sapiens migrated out of Africa into Eurasia remains controversial. We evaluated the role of mtDNA variation in resting metabolic rate (RMR) and total energy expenditure (TEE) among 294 older, community-dwelling African and European American adults from the Health, Aging and Body Composition Study. Common African haplogroups L0, L2 and L3 had significantly lower RMRs than European haplogroups H, JT and UK with haplogroup L1 RMR being intermediate to these groups. This study links mitochondrial haplogroups with ancestry-associated differences in metabolic rate and energy expenditure. |
| Keywords: | Metabolic rate Energetics Mitochondria Mitochondrial haplogroups mtDNA Oxidative phosphorylation |
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