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Alkyne-azide click chemistry mediated carbanucleosides synthesis |
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| Authors: | Broggi Julie Joubert Nicolas Aucagne Vincent Berteina-Raboin Sabine Diez-Gonzalez S Nolan Steve Topalis Dimitri Deville-Bonne Dominique Balzarini Jan Neyts Johan Andrei Graciela Snoeck Robert Agrofoglio Luigi A |
| Institution: | Institut de Chimie Organique et Analytique, UMR 6005, Université d'Orléans, Orléans, France. |
| Abstract: | Hitherto unknown 1,4-disubstituted-1,2,3]-triazolo-4',4'-dihydroxymethyl-3'-deoxy carbanucleosides were synthesized based on a "click approach." Various alkynes were introduced on a key azido intermediate by the "click" 1,3-dipolar Huisgen cycloaddition. Their antiviral activities and cellular toxicities were evaluated on vaccinia virus. None of the synthesized compounds exhibited a significant antiviral activity. |
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