Capturing cellular machines by systematic screens of protein complexes |
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Authors: | Gagneur Julien David Lior Steinmetz Lars M |
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Affiliation: | European Molecular Biology Laboratory, Heidelberg 69117, Germany. |
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Abstract: | Two recent studies have provided the most complete screen for protein complexes in yeast to date, in which partners were identified for approximately half of the proteome. A comparison shows that these two datasets are complementary. In addition, one of the analyses points to a modular organization of the cellular protein network. These data will prove useful in defining principles and trends that arise when combining large-scale datasets of different natures, and in deriving properties of protein machines in cellular systems. |
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