Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1 |
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Authors: | A B Lassar M J Thayer R W Overell H Weintraub |
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Institution: | Department of Genetics, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104. |
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Abstract: | Transformation of myoblasts by activated ras inhibits myogenic differentiation. We demonstrate that this oncogene inhibits expression of the muscle regulatory factors MyoD1 and myogenin. Expression of retroviral-encoded MyoD1 in ras-transformed myoblasts leads to the re-expression of both terminal differentiation markers and lineage markers expressed in proliferating myoblasts (including endogenous MyoD1 and myogenin), suggesting that ras inhibits myogenic differentiation in a manner dependent on the loss of MyoD1 expression. In addition, we show that fos transformation of myoblasts inhibits muscle differentiation by a similar mechanism. |
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