Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5) |
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| Authors: | Hisayuki Amano Ken Itakura Masayoshi Maruyama Tomoko Ichisaka Masato Nakagawa Shinya Yamanaka |
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| Affiliation: | (1) Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan;(2) CREST, Japan Science and Technology Cooperation, Kawaguchi, Japan;(3) Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan |
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| Abstract: | Background Embryonic stem cell-specific gene (ESG) 1, which encodes a KH-domain containing protein, is specifically expressed in early embryos, germ cells, and embryonic stem (ES) cells. Previous studies identified genomic clones containing the mouse ESG1 gene and five pseudogenes. However, their chromosomal localizations or physiological functions have not been determined. |
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