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Mutacin H-29B is identical to mutacin II (J-T8) |
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| Authors: | Guillaume Nicolas Hélène Morency Gisèle LaPointe Marc C Lavoie |
| Institution: | 1. Département de Biochimie et Microbiologie, Faculté des Sciences et Génie, Université Laval, G1K 7P4, Quebec, Quebec, Canada 2. Centre de Recherche en Sciences et Technologie du Lait (STELA), Institut des Nutraceutiques et des Aliments Fonctionnels (INAF), Faculté des Sciences de 1' Agriculture et de 1' Alimentation, Université Laval, G1K 7P4, Québec, Canada 3. Department of Biological and Chemical Sciences, Faculty of Pure and Applied Sciences, The University of the West Indies, Cave Hill Campus, 11000, Bridgetown, BB, Barbados |
| Abstract: | BackgroundStreptococcus mutans produces bacteriocins named mutacins. Studies of mutacins have always been hampered by the difficulties in obtaining active liquid preparations of these substances. Some of them were found to be lantibiotics, defined as bacterial ribosomally synthesised lanthionine-containing peptides with antimicrobial activity. The goal of this study was to produce and characterize a new mutacin from S. mutans strain 29B, as it shows a promising activity spectrum against current human pathogens. |
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