Reticulo-Endothelial Activity in Mice Infected with Plasmodium vinckei |
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| Authors: | F. E. G. COX D. L. J. BILBEY T. NICOL |
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| Affiliation: | Department of Anatomy, Faculty of Medical Sciences, King's College of the University of London, England |
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| Abstract: | SYNOPSIS. The effect of P. vinckei infections on the phagocytic activity of the reticulo-endothelial system in mice has been investigated. Changes occurring in the pattern of R.E. activity show that there is slight stimulation of phagocytosis 24 hours after the initiation of the infection at which time parasites appear in the blood. The stimulation continues and reaches a peak on the 3rd day, following which it drops to subnormal levels by the 6th and 7th days when the animals die. The parasitaemia rises abruptly from the 4th day onwards, this increase bearing a direct relationship to the fall in the level of phagocytic activity. The changes which occur during this infection are compared with those previously reported for Plasmodium gallinaceum in chicks. |
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