Modification of the polar head group of platelet-activating factor: influence on the biological activity |
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| Authors: | G Ostermann H P Kertscher A Lang U Till |
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| Affiliation: | 1. School of Manufacturing Science Engineering, Sichuan University, Chengdu 610065, PR China;2. The Analysis and Testing Centre, Sichuan University, Chengdu 610065, PR China;3. Aviation Maintenance Engineering Department, Chengdu Aeronautic Vocational and Technical College, Chengdu 610100, PR China |
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| Abstract: | Racemic analogues of platelet-activating factor and its lyso derivatives have been prepared in which one methyl of the trimethylammonium group has been replaced by ethyl, propyl, allyl, or carboxymethylene. The influence of chemical modification on the biological activity was assessed by measuring platelet aggregation and desensitization. The results point to a crucial role of a positively charged polar head group for the expression of biological activity of platelet-activating factor. There are also some indications of a more non-specific interaction of the polar head group of platelet-activating factor with its platelet binding sites. |
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