Indirect inactivation of rat brain cytosolic diacylglycerol kinase by nucleoside-5'-monophosphate |
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Authors: | Q Chen N Klemm I M Jeng |
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Affiliation: | Missouri Institute of Psychiatry, University of Missouri, Columbia. |
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Abstract: | Cytosolic diacylglycerol kinase was inhibited drastically by nucleoside monophosphate. The inhibition was relatively specific for adenosine-5'-monophosphate (5'-AMP), although uridine-5'-monophosphate was also effective. The effect of 5'-AMP on diacylglycerol kinase appeared to be indirect since the degree of inhibition lessened with the dilution of the cytosol and the more purified enzyme failed to respond to 5'-AMP. A 5'-AMP-dependent mediator is proposed to be involved in the inactivation of diacylglycerol kinase. |
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