Role of heparan sulfate in fibroblast growth factor signalling: a structural view. |
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| Authors: | L Pellegrini |
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| Institution: | Department of Biochemistry, University of Cambridge, UK. luca@cryst.bioc.cam.ac.uk |
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| Abstract: | Fibroblast growth factors (FGFs) are among the best-studied heparin-binding proteins, and heparan sulfate proteoglycans regulate FGF signalling by direct molecular association with FGF and its tyrosine kinase receptor, FGFR. Two recently determined crystal structures of FGF-FGFR-heparin complexes have provided new structural information on how heparin binds to FGF and FGFR, and lead to different models for receptor dimerisation. |
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