Acanthamoeba produces disseminated infection in locusts and traverses the locust blood-brain barrier to invade the central nervous system |
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| Authors: | Parisa N Mortazavi Graham Goldsworthy Ruth Kirk Naveed A Khan |
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| Affiliation: | (1) School of Biological and Chemical Sciences, Birkbeck, University of London, London, UK;(2) School of Life Sciences, Kingston University, Kingston-Upon-Thames, Surrey, UK;(3) School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK |
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| Abstract: | Background Many aspects of Acanthamoeba granulomatous encephalitis remain poorly understood, including host susceptibility and chronic colonization which represent important features of the spectrum of host-pathogen interactions. Previous studies have suggested locusts as a tractable model in which to study Acanthamoeba pathogenesis. Here we determined the mode of parasite invasion of the central nervous system (CNS). |
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