Role of extracellular matrix and YAP/TAZ in cell fate determination |
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| Institution: | 1. Department of Translational Oncology, Genentech, Inc., South San Francisco, CA 94080, USA;2. Department of Cancer Biology and David H. Koch Center for Applied Research of Genitourinary Cancers, UT MD Anderson Cancer Center, Houston, TX 77054, USA;1. Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln''s Inn Fields, London WC2A 3LY, UK;2. Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, Apartado 14, 2780-156 Oeiras, Portugal;1. Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Changchun City, Jilin Province, 130033, China;2. Division for Endocrine and Minimally Invasive Surgery, Department of Human Pathology in Adulthood and Childhood “G. Barresi,” University Hospital “G. Martino,” University of Messina, Messina, Italy;1. Molecular Immunology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milan, Italy;2. Tumor Immunology Unit, Human Pathology Section, Department of Health Science, Palermo University School of Medicine, 90129 Palermo, Italy;3. Molecular Targets Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy;1. Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Industrial Microbiology Key Lab, College of Biotechnology, Tianjin University of Science and Technology, No 29, 13ST. TEDA, Tianjin 300457, China;2. State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China;3. Anhui Medical University, Hefei 230032, China;4. Beijing Institute of Radiation Medicine, Beijing 102206, China;5. Cell Signaling and Epigenetics Laboratory, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China;6. Department of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Science, 2300 Eye Street, N.W., Washington, DC 20037, USA |
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| Abstract: | The mechanical signals transduced from cellular microenvironment can regulate cell shape and affect cell fate determination. However, how these mechanical signals are transduced to regulate biological processes of cells has remained elusive. Recent studies had elucidated a novel mechanism through which the interactions between mechanical signals from extracellular matrix and cell behavior regulation converged on the function of core components in Hippo signaling pathway, including YAP and TAZ in mammals. Moreover, several very recent studies have found a new crosstalk between Wnt and Hippo signaling in the regulation of cell fate determination. Such mechanism may explain how mechanical signals from microenvironment can regulate cell behavior and determine cell fate. |
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