Homo- and hetero-oligomerization of β2-adrenergic receptor in receptor trafficking,signaling pathways and receptor pharmacology |
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| Institution: | 1. Biochemistry Department, University of Medicine and Pharmacy Victor Babes, Timisoara, Romania;2. Department of Public Health, University of Medicine and Pharmacy Victor Babes, Timisoara, Romania;3. Deparment of Legal Medicine, University of Medicine and Pharmacy Victor Babes, Timisoara, Romania;4. Institute of Legal Medicine, Timisoara, Romania;3. Department of Pharmacology, University of Crete, Heraklion 71003, Greece;4. the Laboratori de Medicina Computacional, Facultat de Medicina, Universitat Autonoma de Barcelona, Bellaterra 08193, Spain;5. the Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Athens 11571, Greece;6. the Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298;3. Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China;4. Institute of Molecular Medicine, Centers for Life Sciences, Peking University, Beijing 100871, China;5. Laboratory of Cardiovascular Science, NIA, National Institutes of Health, Baltimore, Maryland 21224;8. Laboratory of Clinical Investigation, NIA, National Institutes of Health, Baltimore, Maryland 21224;6. Department of Chemistry, Medical University of Lublin, Lublin, Poland;12. SRI International, Menlo Park, California 94025;1. Dental Regenerative Biotechnology Major, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, South Korea;2. Dental Genetics Major, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, South Korea;3. Central Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC), Seoul, South Korea |
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| Abstract: | The β2-adrenergic receptor (β2AR) is the prototypic member of G protein-coupled receptors (GPCRs) involved in the production of physiological responses to adrenaline and noradrenaline. Research done in the past few years vastly demonstrated that β2AR can form homo- and hetero-oligomers. Despite the fact that currently this phenomenon is widely accepted, the spread and relevance of β2AR oligomerization are still a matter of debate. This review considers the progress achieved in the field of β2AR oligomerization with focus on the implications of the receptor–receptor interactions to β2AR trafficking, pharmacology and downstream signal transduction pathways. |
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