Metaxins 1 and 2, two proteins of the mitochondrial protein sorting and assembly machinery,are essential for Bak activation during TNF alpha triggered apoptosis |
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| Institution: | 1. Team 9 (Equipe labellisée Ligue Nationale contre le Cancer), Centre de Recherche en Cancérologie Nantes-Angers, UMR INSERM 892/CNRS UMR 6299, F-44007 Nantes, France;2. Université de Nantes, Faculté de Médecine, 9 Quai Moncousu, 44035 Nantes Cedex 01, France;3. CHU de Nantes, 1 place Alexis-Ricordeau, 44093 Nantes Cedex 1, France;4. Institut de Cancérologie de l''Ouest, Centre René Gauducheau, Saint Herblain, France |
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| Abstract: | The proteins Bax and Bak are central in the execution phase of apoptosis; however, little is known about the partners involved in the control of this complex process. Here, we show that mitochondrial Bak is incorporated into a VDAC2/Mtx1/Mtx2 multi-protein complex in both resting and dying cells. VDAC2 is a porin that has previously been described as a partner of Bak while Mtx1 and Mtx2 are two proteins of the mitochondrial sorting and assembly machinery (SAM) that have been implicated in TNF-induced apoptosis. We show that, after the induction of apoptosis, Bak switches from its association with Mtx2 and VDAC2 to interact with Mtx1. |
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