| 半抗原与载体的最佳分子结合比 |
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| 引用本文： | 荣康泰,徐勤惠,李根令,白燕彬,张丽霞. 半抗原与载体的最佳分子结合比[J]. 中国生物化学与分子生物学报, 1985, 1(2): 27-31 |
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| 作者姓名： | 荣康泰 徐勤惠 李根令 白燕彬 张丽霞 |
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| 作者单位： | 中国人民解放军军事医学科学院药理毒理研究所 北京(荣康泰，徐勤惠，李根令，白燕彬)，中国人民解放军军事医学科学院药理毒理研究所 北京(张丽霞) |
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| 摘 要： | 中国鲎血蓝蛋白、破伤风类毒素、白喉类毒素和牛血清白蛋白与对氧磷偶合为人工抗原时最佳分子结合比分别为300,21-35,19和11mol/mol(10,32-53,30和17mol/15~5daltons)。结合比达6—10mol/10~5daltons以上,都有一定的免疫效果。
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| 关 键 词： | 人工抗原 半抗原与载体的比 对氧磷 血清抗体 抗毒素效应 |
| 收稿时间： | 1985-04-20 |
Optimum Hapten-Carrier Molecular Ratios in Artificial Antigens |
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| Rong Kang-tai Xu Qin-hui Li Gen-ling Bai Yan-bin Zhang Li-xiaInstituse of Pharmacology and Toxicology,Academy of Military Medical Stiences. Optimum Hapten-Carrier Molecular Ratios in Artificial Antigens[J]. Chinese Journal of Biochemistry and Molecular Biology, 1985, 1(2): 27-31 |
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| Authors: | Rong Kang-tai Xu Qin-hui Li Gen-ling Bai Yan-bin Zhang Li-xiaInstituse of Pharmacology Toxicology Academy of Military Medical Stiences |
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| Affiliation: | Rong Kang-tai Xu Qin-hui Li Gen-ling Bai Yan-bin Zhang Li-xiaInstituse of Pharmacology and Toxicology,Academy of Military Medical Stiences. Beijing. |
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| Abstract: | The optimum hapten-carrier molecular ratios of paraoxon conjugated with Ta chypleus tridentatus hemocyanin, tetanus toxoid, diphtheria toxoid and bovine serum albumin are 300, 21-35, 19 and 11 mol/mol (10, 32-53, 30 and 17 mol/ 105daltons), respectively. There is definitive immunological effect as the conjugating ratios above 6-10 mol/105daltons in all artificial antigens studied. |
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| Keywords: | artificial antigen hapten-carrier ratio paraoxon serum antibody antitoxic effect |
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