Molecular mechanisms that regulate auditory hair-cell differentiation in the mammalian cochlea |
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Authors: | Zine Azel |
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Institution: | (1) Institute des Neurosciences de Montpellier, INSERM U583, Université de Montpellier I, 34090 Montpellier, France;(2) Institute of Physiology, University of Lausanne, 1005 Lausanne, Switzerland |
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Abstract: | Mechanosensory hair cells of the vertebrate cochlea offer an excellent developmental system to study cell-fate specification,
and to gain insight into the many human neurological deficits which result in a hearing loss, by affecting primarily the hair
cells. Therefore, there is great interest in studying the molecular mechanisms that regulate their specification and differentiation.
Recent studies, based mostly on loss-of-function experiments that target the role of Notch signaling and basic helix-loop-helix
genes in inner-ear development have indicated that they can regulate mechanosensory hair cell-fate specification and their
initial differentiation. |
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Keywords: | |
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