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Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes |
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| Authors: | Passarella Daniele Favia Raffaele Giardini Alessandra Lesma Giordano Martinelli Marisa Silvani Alessandra Danieli Bruno Efange Simon M N Mash Deborah C |
| Institution: | Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Via Venezian 21, 20133 Milan, Italy. daniele.passarella@unimi.it |
| Abstract: | Synthesis of 7-heteroaryl-2-azabicyclo2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated. |
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