Impaired feedback of gastric functions in carboxypeptidase E-deficient mice |
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Authors: | Friis-Hansen L Rehfeld J F |
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Institution: | Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, DK-2100, Denmark. |
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Abstract: | Carboxypeptidase E deficiency as seen in the fat/fat mice is associated with reduced antral somatostatin content but tripling of the progastrin product. Thus, fat/fat mice are able to maintain normal tissue concentrations of bioactive alpha-amidated gastrin in spite of grossly attenuated progastrin processing. After induction of achlorhydria, however, neither the amount of alpha-amidated gastrin nor the total progastrin product increased in the fat/fat mice. This is contrary to what is seen in wild-type mice. Furthermore, the synthesis of antral somatostatin and fundic chromogranin A is also abnormal. Hence the results suggest a breakdown in the feedback loop that regulates gastric acid secretion. |
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