Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis |
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| Authors: | Laure-Emmanuelle Zaragosi Brigitte Wdziekonski Kevin Le Brigand Phi Villageois Bernard Mari Rainer Waldmann Christian Dani Pascal Barbry |
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| Affiliation: | 1.Centre National de la Recherche Scientifique,Institut de Pharmacologie Moléculaire et Cellulaire, UMR-6097,Valbonne Sophia-Antipolis,France;2.University of Nice Sophia-Antipolis,Nice Cedex 2,France;3.Centre National de la Recherche Scientifique,Institut de Biologie du Développement et Cancer, UMR6543,Nice cedex 2,France |
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| Abstract: | Background In severe obesity, as well as in normal development, the growth of adipose tissue is the result of an increase in adipocyte size and numbers, which is underlain by the stimulation of adipogenic differentiation of precursor cells. A better knowledge of the pathways that regulate adipogenesis is therefore essential for an improved understanding of adipose tissue expansion. As microRNAs (miRNAs) have a critical role in many differentiation processes, our study aimed to identify the role of miRNA-mediated gene silencing in the regulation of adipogenic differentiation. |
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