A dynamic model for the p53 stress response networks under ion radiation |
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| Authors: | J-P Qi S-H Shao D-D Li G-P Zhou |
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| Institution: | (1) Bio-Informatics Research Center, Donghua University, Shanghai, China;(2) Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, U.S.A. |
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| Abstract: | Summary. P53 controls the cell cycle arrest and cell apoptosis through interaction with the downstream genes and their signal pathways.
To stimulate the investigation into the complicated responses of p53 under the circumstance of ion radiation (IR) in the cellular
level, a dynamic model for the p53 stress response networks is proposed. The model can be successfully used to simulate the
dynamic processes of generating the double-strand breaks (DSBs) and their repairing, ataxia telangiectasia mutated (ATM) activation,
as well as the oscillations occurring in the p53-MDM2 feedback loop. |
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| Keywords: | : Cellular networks – p53 – MDM2 – IR – DNA damage – Oscillations |
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