On again, off again: the SRC-3 transcriptional coactivator moonlights as a translational corepressor |
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| Authors: | Anderson Paul Kedersha Nancy |
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| Affiliation: | Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA. |
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| Abstract: | In a recent issue of Molecular Cell, Yu et al. (2007) reported that the steroid receptor coactivator-3 (SRC-3) has a novel cytoplasmic function: it activates the translational silencers TIA-1 and TIAR and thus inhibits the translation of proinflammatory cytokines. |
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