红景天苷对运动后自由基和能量代谢改变的影响

目的:探讨红景天苷在运动过程中对自由基和能量代谢相关指标的作用,从抗氧化系统、能量代谢系统等方面研究红景天苷抗运动性疲劳的机制。方法:本研究采用小鼠运动模型,40只雄性小鼠随机取分为4组(n=10):红景天苷运动组,红景天苷安静组,运动对照组,安静对照组。红景天苷运动组和安静组两组以150 mg/(kg.d)的红景天苷灌胃给药,运动和安静对照组两组以同样体积蒸馏水灌胃,连续给药2周;末次灌胃30 min后,运动组进行无负重游泳120 min,然后测定与运动性疲劳相关的生化指标。结果:研究结果表明,红景天苷能够提高运动小鼠肝脏内超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)等抗氧化酶活性,降低丙二醛(MDA)含量;红景天苷具有稳定运动小鼠血糖,增加肝、肌糖原储备,防止长时间运动后血糖和肝、肌糖原水平降低的作用;红景天苷可提高运动小鼠血浆总胆固醇(TC)、甘油三酯(TG)及游离脂肪酸(FFA)的水平,有影响不同状态下的脂肪代谢,促进脂肪利用的作用。结论:红景天苷对运动过程中自由基和能量代谢改变的影响是其抗运动性疲劳的机制之一。

Influence of salidroside from Rhodiola Sachalinensis A. Bor on some related indexes of free radical and energy metabolism after exercise in mice

Objective: To study the anti-fatigue mechanism of salidroside from Rhodiola SachalinensisA.Bor(SRS)in anti-oxidation and energy metabolic systems in mice,some related indexes of free radical and energy metabolism after exercise were measured.Methods: Forty male mice were divided into four groups(n=10): SRS sport group(SS),SRS quiet group(SQ),sport control group(SC),quiet control group(QC).The mice of SS and SQ groups received SRS solution of 150 ml/kg body weight per day for two weeks,while the mice of SC and QC groups received the same volume of distilled water.30 min after the last treatment,the mice of SS and SC groups were forced to swim for 120 min without loads.then the biochemical parameters related to fatigue were determined.Result: SRS could increase liver superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) activity of antioxidant enzymes and reduce the malondialdehyde(MDA) content,which might increase the body activity of antioxidant enzymes to play the role of anti-oxidation;SRS had some effect of stabilizing blood sugar,increasing liver glycogen and muscle glycogen reserves,preventing blood sugar,liver glycogen and muscle glycogen levels from reducing in long time exercise on mice;SRS could increase plasma total cholesterol(TC),triglyceride(TG) and free fatty acid(FFA) levels in exercise mice,and it had some effect on metabolism of fat under different conditions,and promoted the use of the role of fat.Conclusion: Influence of SRS on some related indexes of free radical and energy metabolism is one of the mechanisms of anti-exercise-induced fatigue of SRS.