Evaluations of substrate specificity and inhibition at PR/p3 cleavage site of HTLV-1 protease |
| |
| Authors: | Naka Hiromi Teruya Kenta Bang Jeong Kyu Aimoto Saburo Tatsumi Tadashi Konno Hiroyuki Nosaka Kazuto Akaji Kenichi |
| |
| Institution: | Institute for Protein Research, Osaka University, Osaka 565-0871, Japan. |
| |
| Abstract: | Core sequences necessary for substrate recognition and its inhibition at the PR/p3 site of HTLV-1 protease were clarified for the first time. From the cleavage rates of peptides containing a part of the PR/p3 site, a heptapeptide was found to be the minimal sequence required for substrate recognition. The use of synthetic inhibitors containing hydroxyethylamine dipeptide isostere indicated that a tetrapeptide sequence was necessary to achieve potent inhibition. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
