分娩方式对北京地区持续母乳喂养的34周龄婴儿肠道菌群影响 |
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引用本文: | 方圆,李玭,武微,熊倩,律娜,朱宝利,张玉梅. 分娩方式对北京地区持续母乳喂养的34周龄婴儿肠道菌群影响[J]. 微生物学报, 2021, 61(11): 3642-3652 |
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作者姓名: | 方圆 李玭 武微 熊倩 律娜 朱宝利 张玉梅 |
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作者单位: | 中国科学院微生物研究所, 病原微生物与免疫学重点实验室, 北京 100101;中国科学院大学, 北京 100049;北京大学公共卫生学院, 北京 100191 |
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基金项目: | 国家重点研发计划(2018YFC1603803,2017YFD0400602) |
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摘 要: | [目的] 比较持续母乳喂养条件下不同分娩方式的34周龄婴儿肠道菌群差异,探讨分娩方式对较大婴儿肠道菌群发育的影响。[方法] 在北京地区招募健康足月分娩母乳喂养婴儿,在34周仍然参与随访的持续母乳喂养婴儿共21例,其中剖宫产婴儿16例、阴道分娩婴儿5例,进行肠道菌群的16S rRNA检测。[结果] 两组共21个粪便样本中,共注释到6个门,分别为:疣微菌门、变形菌门、梭杆菌门、厚壁菌门、放线菌门和拟杆菌门;两组共21个样本中共有57个OTU注释到属水平,其中,26个属水平OTU被注释到厚壁菌门,18个属水平OTU被注释到变形菌门,6个属水平OTU被注释到放线菌门,5个属水平OTU被注释到拟杆菌门,梭杆菌门、疣微菌门各有1个属水平OTU被注释。其中变形菌门在阴道分娩组(44.17%)肠道菌群中的含量高于剖宫产组(16.10%);而放线菌门在阴道分娩婴儿(0.00%)肠道菌群中的含量低于剖宫产婴儿(0.09%)。阴道分娩组与剖宫产组相比,共有7个菌属的丰度发生了显著降低(P<0.05),分别为副杆菌属、葡萄球菌属、嗜血杆菌属、乳杆菌属、肠球菌属、双歧杆菌属及一注释到科水平的毛螺旋菌科OTU。[结论] 分娩方式对持续母乳喂养的婴儿肠道菌群结构存在影响,且这种影响在出生后34周仍然存在。
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关 键 词: | 肠道菌群 婴儿 分娩方式 |
收稿时间: | 2021-02-07 |
修稿时间: | 2021-03-24 |
The impact of delivery mode on the gut microbiota of 34-week-old infants continuously breastfed in Beijing |
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Affiliation: | CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;University of Chinese Academy of Sciences, Beijing 100049, China;School of Public Health, Peking University, Beijing 100191, China |
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Abstract: | [Objective] To compare the differences in gut microbiota in 34-week-old infants under continuous breastfeeding with different delivery modes, and to explore the impact of delivery modes on the development of infant gut microbiota.[Methods] Healthy full-term breast-fed infants were recruited and 21 infants were still participating in follow-up at 34 weeks, including 16 infants delivered by cesarean and 5 vaginal delivered infants. The 16S rRNA of the gut microbiota was detected. [Results] The two groups of 21 samples contained 6 phyla: Actinobacteria, Bacteroides, Firmicutes, Fusobacteria, Proteobacteria and Verrucomicrobia; 57 genera were found. Among them, there are 26 genera in Firmicutes, 18 genera in Proteobacteria, 6 genera in Actinomycota, 5 genera in Bacteroides, 1 genera in Fusobacteria and 1 genera Verrucomicrobia. Among them, the content of Proteobacteria in the gut microbiota of the vaginal delivery group (44.17%) was higher than that in the cesarean section (16.10%); and the content of Actinomycetes in the gut microbiota of vaginal delivery infants (0.00%) was lower than cesarean delivery babies (0.09%). At the genus level, compared with the cesarean section group, the abundance of a total of 7 microorganisms in the vaginal delivery group was significantly reduced (P<0.05), namely Staphylococcus, Lactobacillus, Parabacteroides, Enterococcus, Haemophilus, Bifidobacterium and an OTU of Enterobacteriaceae. [Conclusion] The mode of delivery has an impact on gut microbiota of infants continued breastfeeding, and this impact still exists at 34 weeks after birth. |
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Keywords: | gut microbiota infant delivery mode |
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