| Wnt信号通路抑制因子SFRP1在肿瘤中的研究进展 |
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| 引用本文： | 郑枫芸,李继承. Wnt信号通路抑制因子SFRP1在肿瘤中的研究进展[J]. 细胞生物学杂志, 2007, 29(6): 805-808 |
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| 作者姓名： | 郑枫芸 李继承 |
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| 作者单位： | 浙江大学细胞生物学研究所 杭州310058 |
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| 摘 要： | 定位于染色体8p11.2上的分泌型卷曲相关蛋白1(secreted frizzled related protein 1,SFRP1)基因,是近来发现的新的抑癌基因。因其编码Wnt信号通路抑制因子SFRP1,SFRP1基因失活可导致Wnt信号转导途径的紊乱,影响肿瘤的发生发展。近年来国内外对SFRP1在恶性肿瘤的失活机制进行了一系列的研究,现对这方面的工作进展进行综述。
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| 关 键 词： | 肿瘤 Wnt信号通路 分泌型卷曲相关蛋白1 |
| 收稿时间： | 2007-05-23 |
| 修稿时间： | 2007-07-15 |
Progress in Wnt Signal Pathway Antagonists SFRP1 in Cancer |
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| Feng-Yun Zheng,Ji-Cheng Li. Progress in Wnt Signal Pathway Antagonists SFRP1 in Cancer[J]. Chinese Journal of Cell Biology, 2007, 29(6): 805-808 |
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| Authors: | Feng-Yun Zheng Ji-Cheng Li |
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| Abstract: | The secreted frizzled related protein 1 (SFRP1) gene, which is located on chromosome 8p11.2, has recently been demonstrated to be a new tumor suppressor gene. Since SFRP1 gene encodes a Wnt signaling antagonist, it causes deregulation of Wnt signaling by inactivation, and finally affects human tumorigenesis and progression. A series of researches about the inactive mechanism of SFRP1 in human malignancies have been done in recent years, and now we review them in this article. |
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| Keywords: | cancer Wnt signal pathway secreted frizzled related protein 1 |
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