Role of Glutamate in the Mechanisms of Adaptation of the System of Respiratory Control in Rats to Intermittent Hypoxia |
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Authors: | E É Kolesnikova V I Nosar I N Mankovskaya |
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Institution: | (1) Department of Zoology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada;(2) Department of Biological Sciences, California State University, East Bay, 25800 Carlos Bee Blvd., Hayward, CA 94542, USA;(3) Ecology and Evolutionary Biology, School of Biological Sciences, University of California, Irvine, CA 92697, USA;(4) Department of Zoophysiology, Aarhus University, 8000, Aarhus C, Denmark |
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Abstract: | In experiments on Wistar rats, we studied the role of changes in the state of glutamatergic transmission in the course of
adaptation of the system of respiratory control to intermittent hypoxia. The volume/temporal parameters of respiration were
estimated according to characteristics of EMG activity (amplitude, integral intensity of EMG discharges) recorded from the
diaphragmatic muscle. Changes in EMG activity of the diaphragm induced by acute hypoxia (breathing a 12% О2-containing gas mixture) were estimated before and after of a 14-day-long course of intermittent hypoxia trainings and before
and after inductions of a blocker of NMDA receptors, МK-801. The results prove that the glutamatergic transmitter system is
significantly involved in the reaction of the respiratory system to presentation of a hypoxic stimulus within all stages of
formation of the ventilatory response, both before and after the action of intermittent hypoxia. Blocking of NMDA receptors
under conditions of adaptation to intermittent hypoxia exerted a more intense influence on the amplitude of respiratory EMG
discharges of the diaphragm than on their frequency. |
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