Anatomical mapping of choline acetyltransferase (ChAT)-like and glutamate decarboxylase (GAD)-like immunoreactivity in outer hair cell efferents in adult rats |
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Authors: | Bernhard J Dannhof Girgit Roth Volkmar Bruns |
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Institution: | (1) Zoologisches Institut der J.W. Goethe-Universität, Siesmayerstrasse 70, W-6000 Frankfurt am Main 11, Federal Republic of Germany |
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Abstract: | Summary The distribution of choline acetyltransferase (ChAT)-like and glutamate decarboxylase (GAD)-like immunoreactivity in the cochleae of 15 adult Wistar white rats was investigated using the peroxidase-antiperoxidase (PAP) technique. A monoclonal antibody to ChAT and a polyclonal antiserum to GAD were used. Immunoreaction was investigated quantitatively, in the electron microscope, on tangential sections of the tunnel of Corti and the rows of outer hair cells. ChAT-like and GAD-like immunoreactivity was found in all efferent nerve fibres in the tunnel of Corti and in all efferent synapses on the outer hair cells. A coexistence of ChAT and GAD in the efferent system to the outer hair cells of the rat is therefore assumed. |
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Keywords: | Cochlear efferents Immuno-electron microscopy Choline acetyltransferase Glutamate decarboxylase Rat (Wistar) |
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