Studies on the resistance of a congenic resistant strain of mice (DKIR) against infection with Salmonella enteritidis (author's transl)]

A congenic strain of mice (DKIR) having a relatively resistant gene for mouse typhoid was established by the beckcross mating between C3H/He and DKI strains. DKI strain is highly and uniformly susceptible to the infection with Salmonella enteritidis and C3H/He is relatively resistant to that infection. The present paper reported the consistency of resistance to Salmonella infection of DKIR strain throughout generations after 10 backcross matings. Difference of the number of infected organisms in the peritoneal fluid and organs between DKIR and DKI or C3H/He strains was also described. The newly established DKIR strain seems to be a suitable experimental animal for the study of genetical resistance for mouse typhoid when compared with its original DKI strain.