| 苦参素对单侧输尿管梗阻大鼠肾间质纤维化的保护作用 |
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| 引用本文： | 高红宇,易艳,黄晓丽,邵菊芳,何晓峰,刘晓城. 苦参素对单侧输尿管梗阻大鼠肾间质纤维化的保护作用[J]. 中国组织化学与细胞化学杂志, 2006, 15(2): 190-194 |
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| 作者姓名： | 高红宇 易艳 黄晓丽 邵菊芳 何晓峰 刘晓城 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院肾病科,武汉,430030 |
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| 摘 要： | 目的探讨苦参素对单侧输尿管梗阻(UUO)大鼠肾间质纤维化的影响及可能机制。方法45只雄性SD大鼠随机分为3组:A假手术组,B单侧输尿管结扎(UUO)组,C治疗组。治疗组在UUO的基础上每天以苦参素100mg/Kg/d腹腔注射。B组和C组于术后第7,14,21,28分别处死5只大鼠,A组于第28天处死大鼠。用PAS及Masson染色法观察肾脏病理改变。用免疫组化法检测转化生长因子β1(transforming growth factor-beta1 TGF-β1),α-平滑肌肌动蛋白(alpha-smooth muscle actin-αSMA),Ⅰ型胶原(collagenⅠColⅠ)的表达。结果与UUO组相比,治疗组梗阻侧肾脏TGF-β1,-αSMA,ColⅠ的表达明显减少,肾小管损害和肾间质纤维化的程度也明显减轻。结论苦参素可通过下调TGF-β1,减少肾小管上皮细胞转分化而减轻肾间质纤维化。
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| 关 键 词： | 苦参素 肾间质纤维化 单侧输尿管梗阻 |
| 收稿时间： | 2005-10-18 |
| 修稿时间： | 2005-12-02 |
THE PROTACTIVE EFFECT OF OXYMATRINE ON RENAL INTERSTITIAL FIBROSIS AFTER UNILATERAL URETERAL OBSTRUCTION IN RATS |
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| Gao Hong yu,Yi Yan,Huang Xiaoli,Shao Jufang,He Xiaofeng,Liu Xiaocheng. THE PROTACTIVE EFFECT OF OXYMATRINE ON RENAL INTERSTITIAL FIBROSIS AFTER UNILATERAL URETERAL OBSTRUCTION IN RATS[J]. Chinese Journal of Histochemistry and Cytochemistry, 2006, 15(2): 190-194 |
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| Authors: | Gao Hong yu Yi Yan Huang Xiaoli Shao Jufang He Xiaofeng Liu Xiaocheng |
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| Affiliation: | Department of Nephrology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | |
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| Keywords: | Oxymatrine Renal interstitial fibrosis Unilateral ureteral obstruction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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