Role of Na+/K+-stimulated adenosine triphosphatase in the action of dopaminergic-D2 receptors of the liver in rats |
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Authors: | Abdulrahim Abu-Jayyab Ahmed Mahgoub |
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Institution: | (1) Department of Pharmacology, College of Pharmacy, King Saud University, PO Box 2457, 1145 Riyadh, Saudi Arabia |
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Abstract: | The dopamine receptor agonist, bromocriptine, in a dose of 10 mg/kg i.p. for 14 days, in rats caused a significant increase in liver Na+/K+-ATPase activity, whereas sulpiride, a dopamine receptor antagonist, in a dose of 10 mg/kg, i.p. for 14 days, in rats, caused a significant decrease in liver Na+/K+-ATPase activity. Injection of bromocriptine and sulpiride simultaneously in a group of rats, under the same conditions and using the same doses caused a complete block of both stimulatory activity of bromocriptine and inhibitory activity of sulpiride on liver Na+/K+-ATPase activity. It is suggested that Na+/K+-ATPase may have a role in the action of dopaminergic-D2 receptors. |
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Keywords: | bromocriptine dopaminergic receptor Na+/K+-ATPase sulpiride |
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