Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines |
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Authors: | Wright S W Hageman D L McClure L D Carlo A A Treadway J L Mathiowetz A M Withka J M Bauer P H |
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Affiliation: | Pfizer Central Research, Groton, CT 06340, USA. stephen_w_wright@groton.pfizer.com |
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Abstract: | Anilinoquinazolines currently of interest as inhibitors of tyrosine kinases have been found to be allosteric inhibitors of the enzyme fructose 1,6-bisphosphatase. These represent a new approach to inhibition of F16BPase and serve as leads for further drug design. Enzyme inhibition is achieved by binding at an unidentified allosteric site. |
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