The HIV Tat protein affects processing of ribosomal RNA precursor |
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| Authors: | Donatella Ponti Maria Troiano Gian Carlo Bellenchi Piero A Battaglia Franca Gigliani |
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| Affiliation: | 1.Dipartimento di Biotecnologie Cellulari ed Ematologia,Università La Sapienza,Roma,Italia;2.Dipartimento di Biologia Cellulare e Neuroscienze,Istituto Superiore di Sanità,Roma,Italia;3.Istituto di Genetica e Biofisica "Adriano Buzzati Traverso", CNR,Napoli,Italia |
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| Abstract: | Background Inside the cell, the HIV Tat protein is mainly found in the nucleus and nucleolus. The nucleolus, the site of ribosome biogenesis, is a highly organized, non-membrane-bound sub-compartment where proteins with a high affinity for nucleolar components are found. While it is well known that Tat accumulates in the nucleolus via a specific nucleolar targeting sequence, its function in this compartment it still unknown. |
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