Distribution of (14C)MCA and its derivatives in mouse tissues (author's transl) |
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Authors: | C Malaveille B Duperray H Pacheco L Tomatis |
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Affiliation: | 1. Service de Chimie Biologique, Institut National de Sciences Appliquées de Lyon, 20 avenue Albert Einstein, 69 VilleurbanneFrance;2. Centre International de Recherche sur le Cancer, 150 cours Albert Thomas, 69008 LyonFrance |
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Abstract: | Distribution of [14C]MCA and its derivatives in mouse tissuesThe distribution of radioactivity due to 3-methylcholanthrene (MCA) and/or its metabolites was evaluated in different organs of mothers, foetuses and newborns at 6 and 60–66 h following a single intragastric administration of 1 mg of [14C]MCA to pregnant CF-1 mice. The extent of bound [14C]MCA nd/or its metabolites to nuclear and cytoplasmic proteins was evaluated in organs which were proven to be either susceptible (lung) or non-susceptible (kidney) to the carcinogenic effect of MCA. The present data indicate a slightly higher level of free and bound MCA in the subcellular fractions of the lung than in the kidney and concurrently a higher level of covalently bound MCA to the nuclear DNA in the lungs than in the kidney. |
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Keywords: | MCA methyl-3-cholanthrène Nucléosol protéines solubles des noyaux NRP protéines résiduelles nucléaires ou protéines acides nucléaires PAC protéines acides de la chromatine ou protéines non histones PM poids moléculaire TCA acide trichloracétique |
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