| 多聚磷酸盐及其在分枝杆菌中的生理功能 |
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| 引用本文： | 石廷玉,董兴高,谢建平. 多聚磷酸盐及其在分枝杆菌中的生理功能[J]. 微生物学报, 2016, 56(12): 1840-1846 |
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| 作者姓名： | 石廷玉 董兴高 谢建平 |
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| 作者单位： | 湖北民族学院医学院, 生物资源保护与利用湖北省重点实验室, 湖北 恩施 445000,湖北民族学院医学院, 生物资源保护与利用湖北省重点实验室, 湖北 恩施 445000,西南大学生命科学学院现代生物医药研究所, 重庆市三峡库区生态环境与生物资源省部共建重点实验室(培育基地), 重庆 400715 |
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| 基金项目： | 国家自然科学基金面上项目（81271882）；湖北民族学院博士科研启动金（MY2015B024） |
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| 摘 要： | 结核病仍然是全球性传染病。缩短疗程的新药和新疫苗是控制结核病的关键。研究分枝杆菌的生理功能有助于实现上述目的。多聚磷酸盐在细菌胁迫应答中发挥重要作用。结核分枝杆菌具有两类多聚磷酸盐代谢酶以控制细胞内多聚磷酸盐的动态平衡:多聚磷酸盐激酶和多聚磷酸酸盐水解酶。本文综述多聚磷酸盐在分枝杆菌中的代谢及其生理功能,以期为研究多聚磷酸盐在结核分枝杆菌中的生理功能提供参考。
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| 关 键 词： | 分枝杆菌 多聚磷酸盐 多聚磷酸盐激酶 多聚磷酸盐水解酶 胁迫应答 严紧反应 |
| 收稿时间： | 2016-04-14 |
| 修稿时间： | 2016-05-26 |
Polyphosphate and its physiological function in Mycobacteria-A review |
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| Tingyu Shi,Xinggao Dong and Jianping Xie. Polyphosphate and its physiological function in Mycobacteria-A review[J]. Acta microbiologica Sinica, 2016, 56(12): 1840-1846 |
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| Authors: | Tingyu Shi Xinggao Dong Jianping Xie |
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| Affiliation: | Medical College of Hubei Institute for Nationalities Key Laboratory of Hubei Province for the Protection and Utilization of Biological Resource, Enshi 445000, Hubei Province, China,Medical College of Hubei Institute for Nationalities Key Laboratory of Hubei Province for the Protection and Utilization of Biological Resource, Enshi 445000, Hubei Province, China and College of Life Science, Southwestern University, Chongqing, the Key Laboratory of Ecological Environment and Biological Resources of the Three Gorges Reservoir Area, Chongqing 400715, China |
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| Abstract: | Tuberculosis is still a global infectious disease. New drugs to shorten the course of treatment and new vaccines are the key points to control tuberculosis. The physiological study of Mycobacteria will contribute to the above-mentioned purposes. Polyphosphate plays an important role in the stress adaptation in bacteria. And there are two classes of enzymes:polyphosphate kinase and exopolyphosphatase involved in the polyphosphate metabolism to control the dynamic equilibrium of polyphosphate level in Mycobacteria. Present paper summarized the progress in metabolism and physiological roles of polyphosphate in Mycobacteria, to provide useful information for studying the physiological function of polyphosphate in Mycobacteria. |
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| Keywords: | Mycobacteria polyphosphate polyphosphate kinase exopolyphosphatase stress adaptation stringent response |
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