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Alterations of class I HLA genes in human colon cancers |
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| Authors: | Menashe Bar-Eli Hector Battifora Martin J. Cline |
| Affiliation: | (1) Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, P.O. Box 653, 84105 Beer Sheva, Israel;(2) Department of Surgical Pathology, City of Hope National Medical Center, Duarte, Calif., USA;(3) Department of Medicine, Center for Health Sciences, University of California at Los Angeles, Los Angeles, Calif., USA |
| Abstract: | Summary Alterations of HLA class I genes were found in 3 of 12 human colon cancers. Rearrangements in HLA class I genes were observed in 2 cancers and amplification of HLA-coding genes was observed in 1 cancer. All 3 cancers were at an advanced stage. No examples of amplification or rearrangement in the HLA genes were found in 10 other tumours of diverse types. No alterations in the  2-microgubulin gene were observed in 22 human solid tumours included in this study. The association between alterations in HLA genes and proto-oncogenes in these tumours is discussed. |
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