Comparative functional analysis of aquaporins/glyceroporins in mammals and anurans |
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Authors: | Carissa M Krane David L Goldstein |
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Institution: | (1) Department of Biology, University of Dayton, 300 College Park, Dayton, Ohio 45469, USA;(2) Department of Biological Sciences, Wright State University, Dayton, Ohio 45435, USA |
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Abstract: | Maintenance of fluid homeostasis is critical to establishing and maintaining normal physiology. The landmark discovery of
membrane water channels (aquaporins; AQPs) ushered in a new area in osmoregulatory biology that has drawn from and contributed
to diverse branches of biology, from molecular biology and genomics to systems biology and evolution, and from microbial and
plant biology to animal and translational physiology. As a result, the study of AQPs provides a unique and integrated backdrop
for exploring the relationships between genes and genome systems, the regulation of gene expression, and the physiologic consequences
of genetic variation. The wide species distribution of AQP family members and the evolutionary conservation of the family
indicate that the control of membrane water flux is a critical biological process. AQP function and regulation is proving
to be central to many of the pathways involved in individual physiologic systems in both mammals and anurans. In mammals,
AQPs are essential to normal secretory and absorptive functions of the eye, lung, salivary gland, sweat glands, gastrointestinal
tract, and kidney. In urinary, respiratory, and gastrointestinal systems, AQPs are required for proper urine concentration,
fluid reabsorption, and glandular secretions. In anurans, AQPs are important in mediating physiologic responses to changes
in the external environment, including those that occur during metamorphosis and adaptation from an aquatic to terrestrial
environment and thermal acclimation in anticipation of freezing. Therefore, an understanding of AQP function and regulation
is an important aspect of an integrated approach to basic biological research. |
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