Zinc inhibits nonheme iron bioavailability in humans |
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Authors: | M Olivares F Pizarro M Ruz |
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Institution: | (1) Institute of Nutrition and Food Technology (INTA), University of Chile, Macul 5540, Casilla, 138-11 Santiago, Chile;(2) Department of Nutrition, Faculty of Medicine, University of Chile, Macul 5540, Casilla, 138-11 Santiago, Chile |
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Abstract: | There is increasing concern about potential negative interactions in combined iron and zinc supplementation. The aim of the
present study was to determine the dose-response effect of zinc, given as a solution, on iron bioavailability. Twenty-two
healthy adult women were selected to participate in the study. Iron, with or without zinc was given as an aqueous solution
on d 1,2,14, and 15 of the study. Iron bioavailability was measured on the basis of erythrocyte incorporation of55Fe or59Fe 14 d after administration. Subjects received 0.5 mg of iron together with graded zinc concentrations (0-11.71 mg). No significant
effect of zinc on iron absorption was found at Zn : Fe molar ratios up to 2 :1. At 5:1,10:1, and 20 :1 molar ratios, a dose-dependent
inhibitory effect on iron absorption was observed (28-40% of iron absorption inhibition; one-way repeated-measures ANOVA,
F = 4.48,p = 0.02). In conclusion, zinc administration combined with iron in an aqueous solution leads to the inhibition of iron bioavailability,
which occurs in a dose-dependent way. This negative interaction should be considered for supplementation programs with both
microminerals. |
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Keywords: | Zinc iron bioavailability interaction humans |
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