An association between a lymphocyte antigen in sheep and the response to vaccination against the parasite Trichostrongylus colubriformis |
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Authors: | P M Outteridge R G Windon J K Dineen |
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Institution: | CSIRO Division of Animal Health, McMaster Laboratory, Private Bag No. 1, P.O., Glebe, N.S.W. 2037, Australia |
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Abstract: | Lymphocyte antigens were tested in sheep which had been selected for responsiveness to vaccination against the intestinal nematode Trichostrongylus colubriformis. These sheep had been bred in an assortative mating programme which produced offspring designated as either “high responders” or “low responders”, with highly heritable resistance or susceptibility.Ovine lymphocyte antigen (OLA) typing antisera were obtained from parous ewes in the course of matings which produced the high and low responder flocks. A particular antigen (SY1) was found to be present in high frequency on the lymphocytes of high responder (72·2%) and in lower frequency (21·9%) on the lymphocytes of low responder rams. In ewes, the frequency for high responders was 65·7% and for low responders it was 33·5%. A similar association between the SY1 antigen and low faecal egg count was found in random-bred sheep which had been vaccinated with irradiated larvae and challenged with normal larvae. The conclusion was drawn that this lymphocyte antigen was likely to be part of the sheep major histocompatibility complex which influenced the immune response of sheep to vaccination against the parasite. |
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Keywords: | Sheep lymphocyte antigens association with high and low responders vaccination |
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