CD147的研究进展

CD147分子是一种广泛表达于人体多种组织的跨膜糖蛋白,属于免疫球蛋白超家族。CD147在多种肿瘤细胞和组织中高表达,通过诱导基质金属蛋白酶(MMP)的分泌促进了肿瘤的浸润、转移。同时,CD147与炎症反应如类风湿性关节炎、动脉粥样硬化,以及细胞、组织的分化和发育等密切相关。简要综述了CD147参与的多种生理、病理过程。

Advances in the Research of CD147

Overexpression of extracellular matrix metalloproteinase inducer(EMMPRIN or CD147),a member of the immunoglobulin family and a glycosylated transmembrane protein enriched on the surface of tumor cells,promotes invasion,metastasis,growth and survival of malignant cells.The presence and modulation of EMMPRIN in other tissues associated with increased matrix metalloproteinase(MMP)expression suggests that this EMMPRIN-mediated MMP induction could be a common mechanism in nontumoral physiological and/or pathological situations,such as development of cell and tissue,rheumatoid arthritis,artherosclerosis.The recent findings concerning these diverse regulatory mechanisms in various physiological and pathological situations were discussed here.