Role of the CD8+ dendritic cell subset in transmission of prions |
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Authors: | Sethi Shneh Kerksiek Kristen M Brocker Thomas Kretzschmar Hans |
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Institution: | Center for Neuropathology and Prion Research, Ludwig Maximilians University, Feodor-Lynen-Strasse 23, 81377 Munich, Germany. |
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Abstract: | Controversial results have been observed in mouse models regarding the role of lymphoid tissues in prion pathogenesis. To investigate the role of dendritic cells (DC), we used a transgenic mouse model. In this model (CD11c-N17Rac1), a significant reduction of CD8+ CD11c(hi) DC has been described, and the remaining CD8+ DC demonstrate a reduced capacity for the uptake of apoptotic cells. After intraperitoneal prion infection, significantly longer incubation times were observed in CD11c-N17Rac1 mice than in controls, indicating that a defect in CD8+ CD11c(hi) DC significantly impedes neuroinvasion after intraperitoneal infection. In contrast, no distinct differences were observed between CD11c-N17Rac1 mice and controls after oral infection. This provides evidence that oral and intraperitoneal prion infections differ in lymphoreticular requirements. |
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