On the existence of non-cycling germinative cells in human epidermis in vivo and cell cycle aspects of psoriasis |
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Authors: | Seymour Gelfant |
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Affiliation: | Departments of Dermatology and Cell and Molecular Biology, Medical College of Georgia, U.S.A. |
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Abstract: | Abstract. This report deals with the controversies of whether all germinative epidermal cells in human epidermis are in the cycling state and whether stimulated hyperproliferation of psoriatic epidermis is due to a shortening of the cell cycle time or to a recruitment of non-cycling germinative epidermal cells. Experiments were performed on human subjects in vivo . Continuous infusion of [3H]thymidine for 8½ days indicated that 40% of germinative epidermal cells reside in the non-cycling state. Proliferative stimulation by tape stripping indicated recruitment of non-cycling (G0) germinative epidermal cells in both normal and psoriatic skin, and a prolongation (rather than a shortening) of cell cycle traverse in activated psoriatic epidermal cells. |
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