Oxygen dependence of metabolism and cellular adaptation in vertebrate muscles: a review |
| |
Authors: | L G Forgan M E Forster |
| |
Institution: | (1) The New Zealand Institute for Plant & Food Research Limited, Port Nelson, Box 5114, Nelson, 7043, New Zealand;(2) School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, 8140, New Zealand |
| |
Abstract: | The key roles the cardiovascular system play in the complex distribution of blood, and consequently oxygen, have been extensively
studied in vertebrates. Numerous studies have also revealed the complex and varied ways in which tissues cope with compromised
oxygen supply. The links between these two processes are the subject of much current research. This article aims to review
how blood supply influences tissue oxygenation and affects metabolism, and how this might have played a role in the evolution
of the complex muscle arrangements which characterise vertebrates. Muscle tissue is the greatest proportion of body mass in
most vertebrates and undergoes dramatic alterations in metabolism and associated oxygen flux. Special attention is given to
the myotome of fishes, in which the partitioning of the fibre types contrasts with the mosaic arrangement of tetrapods. This
gives us the opportunity to study pure whole vascularised muscle blocks, rather than single fibres, and further explore the
interrelationship between oxygen supply and tissue energetics. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|