| 大鼠心肌缺血／再灌及高脂血症的心肌膜损伤 |
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| 引用本文： | 董传仁,喻学刚,汪学军. 大鼠心肌缺血／再灌及高脂血症的心肌膜损伤[J]. 生物化学与生物物理进展, 1994, 21(4): 347-350 |
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| 作者姓名： | 董传仁 喻学刚 汪学军 |
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| 作者单位： | 湖北医科大学病理生理学教研室;湖北医科大学病理生理学教研室;湖北医科大学病理生理学教研室 |
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| 基金项目： | 国家自然科学基金资助项目. |
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| 摘 要： | 通过大鼠心肌缺血／再灌及高脂血症的模型证实，两者均有明显的生物膜损伤，主要表现为膜磷脂的降低、胆固醇及胆固醇／磷脂比增高、膜脂流动性及膜酶(Ca2+, Mg2+-ATPase)活性降低，这些异常变化与氧自由基引发的脂质过氧化增强或脂质交换有关.
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| 关 键 词： | 磷脂类／药效学 脂质体／药效学 心肌 血液灌注 细胞膜／病理学 |
| 收稿时间： | 1993-05-31 |
| 修稿时间： | 1993-11-29 |
Myocardial Membrane Injury of Myocardlal Ischeimia/Reperfusion and Lipoidaema in Rat |
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| Dong Chuanren,Yu Xuegang and Wang Xuejun. Myocardial Membrane Injury of Myocardlal Ischeimia/Reperfusion and Lipoidaema in Rat[J]. Progress In Biochemistry and Biophysics, 1994, 21(4): 347-350 |
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| Authors: | Dong Chuanren Yu Xuegang Wang Xuejun |
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| Affiliation: | Department of Pathophysiology, Hubei Medical University;Department of Pathophysiology, Hubei Medical University;Department of Pathophysiology, Hubei Medical University |
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| Abstract: | Through the experiment model of the myocardial ischemia/reperfusion and lipoidaemia in rat, both of them obviously induce membrane injury: a drop of membrane phospholipids, an increase in content of free fatty acids, cholesterol and cholesterol/phospholipid ratio, a decrease in membrane lipids fluidity and activity of membrane enzymes (Ca2+, Mg2+-ATPase). These aterations perhaps related to the increase of lipids hyperoxidation induced by free radical and exchange of lipids. |
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| Keywords: | phospholipids/PD liposomes/PD myocardium hemoperfusion cell membrane |
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