Helicase: mystery of progression |
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Authors: | Rajneesh Kumar Gaur |
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Institution: | (1) Bioinformatics Center, University of Pune, Pune, 411 007, India |
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Abstract: | Helicases mode of unwinding the nucleic acids and translocation along single stranded nucleic acids is still a subject of
great curiosity. Based on the energy transduction and electrophilic interactions, we present a model to explain the mode of
action of active helicases. This model considers that both strand separation as well as translocation is active processes
fueled by NTP hydrolysis. The model proposes that the translocation appears to involve creeping of helicase over the ssNA
lattice rather than inchworm movement. |
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Keywords: | Helicase Unwinding nucleic acid Translocation Hypothesis Chemical model |
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