The human apolipoprotein A-II gene is located on chromosome 1 |
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| Authors: | K J Lackner S W Law H B Brewer A Y Sakaguchi S L Naylor |
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| Institution: | 1. Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA;2. Department of Human Genetics, Roswell Park Memorial Institute, Buffalo, New York, USA |
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| Abstract: | Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL). The gene for apoA-II has been localized to the p21----qter region of chromosome 1 in man by Southern blot hybridization analysis of DNA from human-mouse cell hybrids using a cloned human apoA-II cDNA probe. The regional assignment was established using two hybrids carrying a reciprocal translocation involving chromosomes 1 and 2. Comparison with previously established gene loci on chromosomes 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C. On the other hand, apoA-II is not linked to the apoA-I gene, which has been localized previously to chromosome 11. |
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