The activation of phosphatidylinositol turnover is not directly involved in the modulation of neurotransmitter release mediated by presynaptic muscarinic receptors |
| |
Authors: | Mario Marchi Giovanni Fontana Paolo Paudice Maurizio Raiteri |
| |
Institution: | (1) Istituto di Farmacologia e Farmacognosia, Universitá degli Studi di Genova, Viale Cembrano 4, 16148 Genova, Italy |
| |
Abstract: | In the rat cerebral cortex, the comparative effects of various muscarinic agonists on the release of 3H]dopamine (3H]DA), 3H]acetylcholine (3H]ACh), and 3H]5-hydroxytryptamine (3H]5-HT) from superfused nerve endings and on phosphatidylinositol (PI) turnover were studied. Acetylcholine (ACh) was found to be the most potent among the agonists tested on all three release systems examined, and also on the activation of PI turnover. Oxotremorine and bethanechol were very weak agonists when tested as stimulators of PI turnover. However, oxotremorine was very effective as a release modulator, while bethanechol was completely ineffective. Our data suggest that the activation of PI turnover is not directly involved in the modulation of neurotransmitter release mediated by presynaptic muscarinic receptors. |
| |
Keywords: | Presynaptic receptors synaptosomes neurotransmitter release PI turnover |
本文献已被 SpringerLink 等数据库收录! |
|