Role of vacuolar transporter proteins in plant secondary metabolism: Catharanthus roseus cell culture |
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Authors: | Sittiruk Roytrakul Robert Verpoorte |
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Institution: | (1) Division of Pharmacognosy, Section of Metabolomics, Institue of Biology, Leiden University, Gorlaeus Laboratories, P.O. Box 9502, 2300RA Leiden, The Netherlands;(2) National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, 113 Thailand Science Park, Pahonyothin Rd., Klong 1, Klong Luang, Pathumthani, Thailand |
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Abstract: | Here the current status of knowledge on some well-characterized transporters located in the vacuolar membrane is reviewed.
As different cellular compartments and even different cells may be involved in certain steps of a biosynthetic pathway, the
regulation of the flux is not only dependent on structural genes encoding enzymes catabolizing certain steps but also transport
has a major regulatory function. The aim of the present review is to give an overview of the present knowledge of transport
of secondary metabolites in plants, and to use this information in the context of our knowledge about Catharanthus roseus alkaloid biosynthesis. This should lead to further insight in the possible role of various transporters in the regulation
of the biosynthesis of these alkaloids. |
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Keywords: | Catharanthus roseus Secondary metabolism Vacuole Tonoplast Transporter |
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