Cutting edge: human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells |
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Authors: | Misra Namita Bayry Jagadeesh Lacroix-Desmazes Sébastien Kazatchkine Michel D Kaveri Srini V |
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Institution: | Institut National de la Santé et de la Recherche Médicale, Unité 430, and Université Pierre et Marie Curie, Centre de Recherches Biomedicales des Cordeliers, Paris, France. |
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Abstract: | The characteristics and functions of CD4(+)CD25(+) regulatory cells have been well defined in murine and human systems. However, the interaction between CD4(+)CD25(+) T cells and dendritic cells (DC) remains unclear. In this study, we examined the effect of human CD4(+)CD25(+) T cells on maturation and function of monocyte-derived DC. We show that regulatory T cells render the DC inefficient as APCs despite prestimulation with CD40 ligand. This effect was marginally reverted by neutralizing Abs to TGF-beta. There was an increased IL-10 secretion and reduced expression of costimulatory molecules in DC. Thus, in addition to direct suppressor effect on CD4(+) T cells, regulatory T cells may modulate the immune response through DC. |
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