Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin |
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| Authors: | P M Lad C V Olson I S Grewal |
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| Institution: | 1. Guizhou University Medical College, Guiyang 550025, Guizhou Province, China;2. Department of Neurosurgery, Guizhou Provincial People’s Hospital, Guiyang, China;3. Department of Nephrology, Guizhou Provincial People’s Hospital, Guiyang, China;4. Department of Neurology, the Affiliated Dazu Hospital of Chongqing Medical University , China;5. Department of Anesthesiology, Guizhou Provincial People’s Hospital, Guiyang, China;1. Key Surgical Laboratory of Educational Administration of Liaoning Province, First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121012, China;2. Post Graduate School of Jinzhou Medical University, Jinzhou 121001, China;3. Ultrasound Department, First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China;4. Huludao Central Hospital Teaching Base of Jinzhou Medical University, Jinzhou 125001, China |
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| Abstract: | Pretreatment of human neutrophils with pertussis toxin inhibits platelet-activating factor-mediated chemotaxis, superoxide generation, aggregation, and release of lysozyme. By contrast, superoxide generation observed in the presence of phorbol-12-myristate-13 acetate is unaffected. Our results suggest that a target protein for pertussis toxin, probably a GTP binding protein termed "Ni", is involved in the actions of platelet-activating factor on human neutrophils. |
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