Biochemical mechanisms of radiogenic cytogenetic and somatic disorders in children residing in regions polluted by radionuclides

Children and adults affected by the Chernobyl accident suffer with lipoperoxic stress coupled with hypovitaminoses A and E, the syndrome and its radiogenic mechanisms described by the authors previously. The relation of these biochemical disturbances to somatic consequences on mutagenic and teratogenic levels caused by chronic low-dose irradiation of children into radiopolluted regions has been investigated. Either the rational approaches to prevent or/and to treat all pathologies indicated were tested. The radionuclide polluted regions had 1-5, 5-15 and 15-40 Ci/km2 by 137Cs. Unprotected newborns (without the therapy) had vA and vE levels about one third of normal ones for minimal radioloads, the vitamins lowered further for higher Da and/or Dm up to the deep hypovitaminoses or even avitaminoses. Increasing of LPC catabolites levels for children were correlated significantly with their stigmation levels. The therapy-protected newborns had normal ranges of all indices. However, unprotected newborns showed dramatic increase for all of radiogenic indices along with fall of vA and vE, and significant inverse correlations of the indices with retinol levels. The values of radiogenic indices showed hyperbolic-like rise along with growing of vA and vE deficits below their lower limits. The combination of radiogenic biochemical deviations evaluated for Chernobyl contingents is supposed to be the primary molecular mechanisms of somatic mutations and irreversible stigmation. The peroral polyvitamin therapy is proposed as the method of choice for prevention or normalization of revealed pathologies.